O125 Impact of efavirenz and nevirapine on pharmacokinetics of lopinavir/ritonavir as tablets and capsules in African patients

doi:10.1186/1758-2652-11-S1-O10

Journal of the International AIDS Society

Volume 11
Suppl 1

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Kityo C
Walker AS
Lutwana F
Ssali F
Nalumenya R
Tumukunde D
Kawiya J
Munderi P
Reid A
Gilks CF
Gibb DM
Khoo SH

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Kityo C
Walker AS
Lutwana F
Ssali F
Nalumenya R
Tumukunde D
Kawiya J
Munderi P
Reid A
Gilks CF
Gibb DM
Khoo SH
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This article is part of the supplement: Abstracts of the Ninth International Congress on Drug Therapy in HIV Infection .

Oral presentation

O125 Impact of efavirenz and nevirapine on pharmacokinetics of lopinavir/ritonavir as tablets and capsules in African patients

C Kityo¹, AS Walker², F Lutwana³, F Ssali⁴, R Nalumenya³, D Tumukunde⁴, J Kawiya⁵, P Munderi⁶, A Reid⁷, CF Gilks⁸, DM Gibb² and SH Khoo⁹

¹CRC, Uganda, Uganda

²MRC Clinical Trials Unit, London, UK

³Infectious Diseases Institute, Mulago, Uganda

⁴Joint Clinical Trials Unit, London, UK

⁵Joint Clinical Research Centre, Kampala, Uganda

⁶MRC/UVRI Research Unit on AIDS, Entebbe, Uganda

⁷University of Zimbabwe, Harare, Zimbabwe

⁸Imperial College, London, UK

⁹Liverpool University, Liverpool, UK

corresponding author email

from Ninth International Congress on Drug Therapy in HIV Infection
Glasgow, UK. 9–13 November 2008

Journal of the International AIDS Society 2008, 11(Suppl 1):O10doi:10.1186/1758-2652-11-S1-O10


Published:	10 November 2008

First paragraph (this article has no abstract)

With NNRTI, the recommended dose of lopinavir/r (LPV/r) is 4 capsules (533/133 mg) BD. With LPV/r tablets, the closest doses are 2 tablets (400/100 mg) BD or 3 tablets [tabs] (600/150 mg) BD. Improved bioavailability of the tablet suggests that 2 tabs BD should be sufficient, but PK data are few and generally from Caucasians.